Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/35207
Title: T cell responses in Helicobacter pylori - Associated gastroduodenal diseases
Authors: VICTORIA SERELLI LEE SHAN
Keywords: Helicobacter pylori, Th17, Interleukin-17A, Gastric Cancer, Precancerous, Chronic inflammation
Issue Date: 19-Jan-2012
Source: VICTORIA SERELLI LEE SHAN (2012-01-19). T cell responses in Helicobacter pylori - Associated gastroduodenal diseases. ScholarBank@NUS Repository.
Abstract: Gastric cancer is associated with Helicobacter pylori (HP) infection and its development follows a precancerous cascade. Accompanying this is chronic inflammation in the gastric environment which is associated with a significant Th17 response. These responses are triggered upon infection with HP and it is demonstrated here that these responses persist up to a period of 10 years after the infection has been cleared. This persistent inflammation is also characterized by the presence other pro-inflammatory cytokines, and is also associated with precancerous lesions in the gastric mucosa. This thesis establishes the association between chronic inflammation and precancerous lesions and describes the characteristics of this inflammation - the types of cells that are involved and the cytokines that are produced. In vitro studies also provide insight into possible mechanisms by which the chronic inflammation persists even after clearing the bacterial infection.
URI: http://scholarbank.nus.edu.sg/handle/10635/35207
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