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Title: The Role of Serum Amyloid A in atherosclerosis
Authors: TAN SI ZHEN
Keywords: Atherosclerosis, NFκB, Apoptosis
Issue Date: 8-Mar-2012
Citation: TAN SI ZHEN (2012-03-08). The Role of Serum Amyloid A in atherosclerosis. ScholarBank@NUS Repository.
Abstract: Background: Atherosclerosis is responsible for almost 30% of all deaths worldwide, making it a major cause of death, especially in developed countries. Serum amyloid A (SAA), a major acute phase protein, is elevated in atherosclerotic patients. SAA is also suspected to play a direct role in coronary artery disease (CAD). However, the mechanisms through which SAA contributes to atherosclerosis remain unclear. Inflammation is known to play a role in atherosclerosis, with apoptosis being a key event due to its ability to affect plaque stability. Objective: Given the roles of inflammation and apoptosis in atherosclerosis, we hypothesized that SAA may contribute to atherosclerosis via these mechanisms. Methods and Results: We found that SAA (80 µg/mL) induced the expression of targets known to play important roles in the initiation and progression of atherosclerosis (i.e., ICAM-1, MCP-1, MMP-9, and TF through NFkB regulation) 3.5- to 37.8-fold within an hour following exposure. RAW264.7 cells treated with increasing doses of SAA showed regulation of apoptotic targets and a dose-dependent reduction in cell viability, with 69% cell viability observed following exposure to 80 µg/mL SAA for 24 h, using the MTT assay. Conclusion: Our results suggest that SAA may contribute to atherosclerosis via both inflammatory and apoptotic mechanisms.
Appears in Collections:Master's Theses (Open)

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