Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/34984
Title: USE OF ANDROGRAPHOLIDE COMPOUNDS FOR TREATING INFLAMMATION AND AIRWAY DISORDERS
Authors: WONG, WAI SHIU FRED 
Issue Date: 19-Jan-2012
Citation: WONG, WAI SHIU FRED (2012-01-19). USE OF ANDROGRAPHOLIDE COMPOUNDS FOR TREATING INFLAMMATION AND AIRWAY DISORDERS. ScholarBank@NUS Repository.
Abstract: We describe for the first time that andrographolide derivatives such as DDAG effectively reduced OVA-induced inflammatory cell recruitment into BAL fluid, IL-4, IL-5, IL-13 and eotaxin production, serum IgE synthesis, pulmonary eosinophilia, mucus hypersecretion and AHR in a mouse asthma model potentially via inhibition of NF-?B activity. Moreover, low dose of DDAG and glucocorticoid combination treatment synergistically attenuate inflammation in mouse asthma model. These findings support a therapeutic value for DDAG in the treatment of asthma. ##STR00001##
URI: http://scholarbank.nus.edu.sg/handle/10635/34984
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