Please use this identifier to cite or link to this item:
https://scholarbank.nus.edu.sg/handle/10635/34984
Title: | USE OF ANDROGRAPHOLIDE COMPOUNDS FOR TREATING INFLAMMATION AND AIRWAY DISORDERS | Authors: | WONG, WAI SHIU FRED | Issue Date: | 19-Jan-2012 | Citation: | WONG, WAI SHIU FRED (2012-01-19). USE OF ANDROGRAPHOLIDE COMPOUNDS FOR TREATING INFLAMMATION AND AIRWAY DISORDERS. ScholarBank@NUS Repository. | Abstract: | We describe for the first time that andrographolide derivatives such as DDAG effectively reduced OVA-induced inflammatory cell recruitment into BAL fluid, IL-4, IL-5, IL-13 and eotaxin production, serum IgE synthesis, pulmonary eosinophilia, mucus hypersecretion and AHR in a mouse asthma model potentially via inhibition of NF-?B activity. Moreover, low dose of DDAG and glucocorticoid combination treatment synergistically attenuate inflammation in mouse asthma model. These findings support a therapeutic value for DDAG in the treatment of asthma. ##STR00001## | URI: | http://scholarbank.nus.edu.sg/handle/10635/34984 |
Appears in Collections: | Staff Publications |
Show full item record
Files in This Item:
File | Description | Size | Format | Access Settings | Version | |
---|---|---|---|---|---|---|
US20120015923A1.PDF | 874.16 kB | Adobe PDF | OPEN | Published | View/Download |
Google ScholarTM
Check
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.