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Title: Near-Field Coherent Anti-Stokes Raman Scattering (CARS) Microscopy for Bioimaging
Authors: LIN JIAN
Keywords: Coherent anti-Stokes Raman scattering, microscopy, bioimaging, near-field, radial polarization
Issue Date: 19-Jan-2012
Citation: LIN JIAN (2012-01-19). Near-Field Coherent Anti-Stokes Raman Scattering (CARS) Microscopy for Bioimaging. ScholarBank@NUS Repository.
Abstract: Coherent anti-Stokes Raman scattering (CARS) microscopy is a nonlinear Raman imaging technique that has received great attention for biological and biomedical imaging due to its ability of real-time, nonperturbative chemical mapping of live unstained cells and tissue based on molecular vibrations. However, some challenges in CARS microscopy still remain unsolved for its wider biomedical applications. For instance, the strong nonresonant background in CARS imaging deteriorates the image contrast which ultimately limits the sensitivity of CARS technique in bioimaging. The spatial resolution of CARS is limited by the light diffraction (~ submicron scales in resolution), which is unsuited for imaging the inter-/intra- cellular fine structures at nanoscales. Hence, the main objectives of this thesis work are to explore the near-filed CARS microscopy technique for nanoimaging, and to develop new technique for effectively suppressing the nonresonant background for high contrast imaging in biomedical systems.
Appears in Collections:Ph.D Theses (Open)

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