Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/34755
Title: CHARACTERIZATION OF THE ROLE OF PARKIN, A PARKINSON'S DISEASE-LINKED GENE, IN BREAST CANCER
Authors: TAY SHIAM PENG
Keywords: Parkin, Parkinson's disease, breast cancer, Bca3/AKIP1, CDK6, tumor suppressor
Issue Date: 30-Mar-2012
Source: TAY SHIAM PENG (2012-03-30). CHARACTERIZATION OF THE ROLE OF PARKIN, A PARKINSON'S DISEASE-LINKED GENE, IN BREAST CANCER. ScholarBank@NUS Repository.
Abstract: Parkin is a frequent target for mutations and deletions not only in Parkinson¿s disease (PD) but also in several cancer types. Interestingly, while germline mutations of parkin are responsible for PD, somatic parkin mutations are linked to different malignancies, of which breast cancer is one of them. Consistent with this, I have shown that parkin expression was dramatically downregulated both at the transcript and protein levels in a variety of breast cancer cells and primary breast cancer tissues. Importantly, restoration of parkin expression in MCF7, a parkin-deficient breast cell line, was able to mitigate its proliferation rate and migration capacity both in vitro and in vivo. In a related development, I have identified BCA3/AKIP1, a breast cancer-associated protein, as a novel parkin interactor. The findings gathered during my PhD candidature have thus provided important insights into the role of parkin that is relevant to both neurodegeneration and cancer.
URI: http://scholarbank.nus.edu.sg/handle/10635/34755
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