Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/34683
Title: STUDIES ON PELLET COMPOSITION AND FORMATION IN EXTRUSION-SPHERONIZATION
Authors: SRIMANTA SARKAR
Keywords: Extrusion-spheronization, Pelletization, In-process particle size, Packing, Single component pellet, Pellet surface roughness
Issue Date: 18-Jan-2012
Source: SRIMANTA SARKAR (2012-01-18). STUDIES ON PELLET COMPOSITION AND FORMATION IN EXTRUSION-SPHERONIZATION. ScholarBank@NUS Repository.
Abstract: The main focus of this project was to explore pellet composition and formation by extrusion-spheronization. Two types of pelletization aids, microcrystalline cellulose (MCC) and cross-linked polyvinyl pyrrolidone (X-PVP), were characterized for their interactions with the moistening liquid and behavioural changes during the different wet processing steps of extrusion-spheronization. During wet processing, MCC particles de-aggregate into smaller individual particles, whereas the size of X-PVP particles remained largely unaltered. It was observed that the pelletization aid functionality of a material was dependent on its actual in-situ (in process) particle size during the different steps of extrusion-spheronization. Formulations containing pelletization aid with smaller in-process pelletization aid particle size generally produced better quality pellets. Quality of pellets from formulations containing pelletization aid with larger in-process particle size could be improved by adjusting the process and formulation variables. From investigations on different process and formulation approaches, it was proposed that good packing of the component particles was critical for successful pellet production by extrusion-spheronization. As proof of concept, pellets were prepared with merely pharmaceutical fillers or drug without using a pelletization aid. Findings of this project represent a step forward in understanding in the mechanism of pellet formation by extrusion-spheronization.
URI: http://scholarbank.nus.edu.sg/handle/10635/34683
Appears in Collections:Ph.D Theses (Open)

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