Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/34671
Title: Development of calixarenes-capped ß-cyclodextrin-bonded chiral stationary phases for chiral drug separation in high-performance liquid chromatography
Authors: THAMARAI CHELVI
Keywords: calixarene, β-cyclodextrin, enantioseparation, Chiral Stationary Phase, High Performance Liquid Chromatography, bioactivity
Issue Date: 29-Jul-2011
Source: THAMARAI CHELVI (2011-07-29). Development of calixarenes-capped ß-cyclodextrin-bonded chiral stationary phases for chiral drug separation in high-performance liquid chromatography. ScholarBank@NUS Repository.
Abstract: Several new types of calixarenes-capped ß-cyclodextrin (ß-CD)-bonded chiral stationary phases (CSPs) have been successfully synthesized and used for chiral drug separation in high-performance liquid chromatography (HPLC). The new CSPs are characterized by means of elemental analysis and Fourier-transform infrared spectroscopy. The new calixarenes-capped ß-CD-bonded CSPs possess a novel chiral selector with two recognition sites: calixarene and ß-CD. The chromatographic performance of the new CSPs was studied with several disubstituted benzenes and some chiral drug compounds under both normal phase and reversed-phase conditions. Those new CSPs exhibited excellent separation selectivities for separation of aromatic positional isomers and enantiomers of a wide range of chiral compounds due to cooperative functioning of the two recognition sites of the calixarenes-capped ß-CD selectors: calixarenes and ß-CDs. For the first time, determination of different bioactivity of the individual pure enantiomers of two estrogen receptor bioactive drugs, Zearalenol and Vinclozolin, was demonstrated after chiral separation on one of the new CSP-packed columns.
URI: http://scholarbank.nus.edu.sg/handle/10635/34671
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