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Title: Changes in cholesterol metabolome after kainate-induced neurodegeneration
Authors: KIM JI HYUN
Keywords: cholesterol, cholesterol metabolome, neurodegeneration, kainate, hippocampus, COPs
Issue Date: 28-Jul-2011
Citation: KIM JI HYUN (2011-07-28). Changes in cholesterol metabolome after kainate-induced neurodegeneration. ScholarBank@NUS Repository.
Abstract: Cholesterol was increased after kainite (KA)-induced neurodegeneration. The study examined changes to cholesterol metabolome upon KA injury. Cholesterol biosynthesis precursors were significantly increased during early KA insult without increase of regulators, but reduced during neurodegeneration. The increased cholesterol in the affected hippocampus could be due to early response to injury. Increased cholesterol was metabolized to various oxysterols after KA injury, propagating oxidative stress in lesioned hippocampus. Increased oxysterols could exacerbate neuronal injury and inhibit cholesterol efflux. Upon neurodegeneration, cholesterol transporter ABCA1 was increased. However, the altered distribution, expression, and affected availability of free cholesterol, might affect function of ABCA1 which could cause accumulation of cholesterol in the brain. Increased cholesterol was converted to cholesteryl esters by induced ACAT upon KA injury. ACAT activation was observed in oligodendrocytes. Induced conversion of cholesterol to cholesteryl esters was due to increased oxidative stress after KA injury, which could inhibit cholesterol efflux.
Appears in Collections:Ph.D Theses (Open)

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