Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/34475
Title: Role of Phospholipase A2 in Orofacial Pain and Synaptic Transmission
Authors: MA MAY THU
Keywords: phospholipase A2, orofacial pain, carrageenan, neurotransmission
Issue Date: 28-Jul-2011
Source: MA MAY THU (2011-07-28). Role of Phospholipase A2 in Orofacial Pain and Synaptic Transmission. ScholarBank@NUS Repository.
Abstract: Phospholipase A2 (PLA2) are enzymes which hydrolyze the membrane phospholipids to generate arachidonic acid (AA) and lysophospholipids. This study elucidated changes in brain lipids in medulla oblongata after orofacial pain induced by facial carrageenan (CA) injection. The caudal medulla oblongata (CM) showed decreases in phosphatidylethanolamine and phosphatidylinositol and increases in lysophosphatidylethanolamine and lysophosphatidylinositol (lysoPI), indicating an enhanced PLA2 activity in CM and release of AA after peripheral inflammation of the face. sPLA2-III was highly expressed in the CM and was significantly increased in the CA-injected rats. These changes possibly take place in spinal trigeminal nucleus which communicates nociceptive input from orofacial region, indicating the nociceptive function of sPLA2-III. sPLA2¿IIA was also localized in spinal trigeminal nucleus. External application of sPLA2-III and lysoPI induced exocytosis in PC-12 cells. This study demonstrated increased PLA2 activity and expression upon orofacial pain. sPLA2-III and sPLA2-IIA are the important in the ascending pain pathway.
URI: http://scholarbank.nus.edu.sg/handle/10635/34475
Appears in Collections:Ph.D Theses (Open)

Show full item record
Files in This Item:
File Description SizeFormatAccess SettingsVersion 
MAMT Part 1 of 4.pdf8.21 MBAdobe PDF

OPEN

NoneView/Download
MAMT Part 2 of 4.pdf9.65 MBAdobe PDF

OPEN

NoneView/Download
MAMT Part 3 of 4.pdf3.49 MBAdobe PDF

OPEN

NoneView/Download
MAMT Part 4 of 4.pdf1.3 MBAdobe PDF

OPEN

NoneView/Download

Page view(s)

250
checked on Dec 11, 2017

Download(s)

692
checked on Dec 11, 2017

Google ScholarTM

Check


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.