Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/34462
Title: Pleiotropically-acting MicroRNA-10b Regulates Angiogenicity, Invasion and Growth of Tumor Cells Resembling Mesenchymal Subgroup of Glioblastoma Multiforme
Authors: LIN JIA KAI
Keywords: MicroRNA-10b, Glioblastoma multiforme, Angiogenesis, Invasion, Growth, Mesenchymal
Issue Date: 20-Feb-2012
Source: LIN JIA KAI (2012-02-20). Pleiotropically-acting MicroRNA-10b Regulates Angiogenicity, Invasion and Growth of Tumor Cells Resembling Mesenchymal Subgroup of Glioblastoma Multiforme. ScholarBank@NUS Repository.
Abstract: Glioblastoma multiforme (GBM) is a heterogeneous disease despite its seemingly uniform pathology. Deconvolution of The Cancer Genome Atlas¿s GBM gene expression data has unveiled the existence of distinct gene expression signatures underlying discrete GBM subgroups. We showed that silencing of microRNA-10b by baculoviral decoy vectors in a glioma cell line resembling the mesenchymal subgroup of GBM reduces its growth, invasion and angiogenesis whilst promoting apoptosis in vitro. In an orthotopic human glioma mouse model, inhibition of microRNA-10b diminishes the invasiveness, angiogenicity and growth of the mesenchymal glioma cells in the brain and significantly prolonged survival of glioma-bearing mice. We demonstrated that the pleiotropic nature of microRNA-10b was due to its suppression of multiple tumor suppressors including TP53, FOXO3, CYLD, PAX6, PTCH1 and NOTCH1. Thus, our study uncovers a novel role for microRNA-10b in regulating angiogenesis and suggests that microRNA-10b may be a pleiotropic regulator of gliomagenesis.
URI: http://scholarbank.nus.edu.sg/handle/10635/34462
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