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Title: Force-controlled Biomanipulation for Biological Cell Mechanics Studies
Authors: NAM JOO HOO
Keywords: zebrafish, chorion, stiffness, impedance, explicit force control, flexure stage, viscoelastic
Issue Date: 15-Jan-2011
Source: NAM JOO HOO (2011-01-15). Force-controlled Biomanipulation for Biological Cell Mechanics Studies. ScholarBank@NUS Repository.
Abstract: Constantly exposed to various forms of mechanical forces inherent in their physical environment, cellular organisms are able to sense such forces and convert them into biochemical signals through the processes of mechanosensing and mechanotransduction. The two processes eventually lead to physiological and pathological changes in their internal structures and properties, such as stiffness and impedance. This thesis explores the development of an explicit force-controlled system which is capable of applying and controlling a prescribed force on a zebrafish embryo. Two experiments have been conducted to detect and investigate the mechano-induced variation in the properties of a zebrafish chorion. The experimental results demonstrating that application of an external force induced observable change in the impedance and the stiffness of a zebrafish embryo. The experimental data provides evidence supporting the hypothesis that certain physiological properties of some cellular organisms can be modified by applying an appropriate mechanical force.
Appears in Collections:Ph.D Theses (Open)

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