Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.otohns.2004.04.020
Title: Safety and efficacy of radioallergosorbent test-based allergen immunotherapy in treatment of perennial allergic rhinitis and asthma
Authors: Yeoh, K.H. 
Wang, D.Y. 
Gordon, B.R.
Issue Date: 2004
Source: Yeoh, K.H.,Wang, D.Y.,Gordon, B.R. (2004). Safety and efficacy of radioallergosorbent test-based allergen immunotherapy in treatment of perennial allergic rhinitis and asthma. Otolaryngology - Head and Neck Surgery 131 (5) : 673-678. ScholarBank@NUS Repository. https://doi.org/10.1016/j.otohns.2004.04.020
Abstract: This study was undertaken to demonstrate the safety and efficacy of in vitro, radioallergosorbent test (RAST)-based inhalant allergen immunotherapy. Prospective 22 year single site clinical study, with outcome evaluations of 480 perennial allergic rhinitis patients, including 96 with concomitant asthma. Rhinitis symptom control after 2 years of immunotherapy was excellent in 32.5% of patients, good in 45.6%, and fair in 14.2%. There was no improvement in 7.7%. For patients with asthma, 81% had good or excellent pulmonary symptom improvement, and no patient failed to improve. No severe reactions occurred, but there were 5 limited systemic reactions, or 0.008% of injections, during a 2.5-year mean immunotherapy treatment course. RAST-based immunotherapy is safe and effective for patients with perennial allergic rhinitis, with or without concomitant asthma. This is the first large, multiyear study of safety and efficacy of RAST-based immunotherapy for treatment of perennial allergic rhinitis and asthma. EBM rating: C.
Source Title: Otolaryngology - Head and Neck Surgery
URI: http://scholarbank.nus.edu.sg/handle/10635/33982
ISSN: 01945998
DOI: 10.1016/j.otohns.2004.04.020
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