Please use this identifier to cite or link to this item:
|Title:||Analysis of differential gene expression in the cochlea and kidney of mouse by cDNA microarrays|
|Source:||Liu, X., Ruan, R., Mohamed, J.A. (2004). Analysis of differential gene expression in the cochlea and kidney of mouse by cDNA microarrays. Hearing Research 197 (1-2) : 35-43. ScholarBank@NUS Repository. https://doi.org/10.1016/j.heares.2004.04.014|
|Abstract:||Microarray hybridization analysis of gene expression in the cochlea and kidney suggest a relationship between these tissues at the genomic level, indicating the common gene expression, likely serving a common function in both the organs primarily maintaining ion transport, and implied previously from morphological, pharmaco-kinetic and teratogenic studies. The cDNAs of more than 100 genes listed on the hereditary hearing loss homepage were amplified as targets by RT-PCR and were hybridized with probes prepared from total RNA of the cochlea and the kidney. Thirteen of the genes analyzed showed altered fluorescence ratios of more than two logs. Of these, the expressions of 11 genes were over expressed and two were under expressed in the cochlea than in the kidney. Our data is the first report to corroborate the genomic similarities between these two important organs and may help to explain the somewhat similar response of these organs to certain therapeutic drugs. © 2004 Elsevier B.V. All rights reserved.|
|Source Title:||Hearing Research|
|Appears in Collections:||Staff Publications|
Show full item record
Files in This Item:
There are no files associated with this item.
checked on Feb 27, 2018
WEB OF SCIENCETM
checked on Feb 14, 2018
checked on Mar 12, 2018
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.