Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.nimb.2005.01.078
Title: Nuclear microscopy of diffuse plaques in the brains of transgenic mice
Authors: Rajendran, R. 
Ren, M. 
Watt, F. 
Casadesus, G.
Smith, M.A.
Perry, G.
Huang, E. 
Ong, W.Y. 
Halliwell, B. 
Keywords: Alzheimer's disease
Amyloid-β deposit
Nuclear microscopy
PIXE
STIM
Tg2576 transgenic mice
Trace elements
Issue Date: 2005
Source: Rajendran, R., Ren, M., Watt, F., Casadesus, G., Smith, M.A., Perry, G., Huang, E., Ong, W.Y., Halliwell, B. (2005). Nuclear microscopy of diffuse plaques in the brains of transgenic mice. Nuclear Instruments and Methods in Physics Research, Section B: Beam Interactions with Materials and Atoms 231 (1-4) : 326-332. ScholarBank@NUS Repository. https://doi.org/10.1016/j.nimb.2005.01.078
Abstract: Using nuclear microscopy, extracellular diffuse amyloid deposits in fresh unstained brain tissue from Alzheimer's disease transgenic mice Tg2576 have been identified and analyzed for trace element content. Off-axis scanning transmission ion microscopy (STIM) images can be obtained which are similar to the images produced using direct STIM. Since the proton beam current required for off-axis STIM is compatible with PIXE and RBS, we can identify the plaque location and analyze for trace elements simultaneously. Analysis of the diffuse plaques showed an increase in the transition metals iron and zinc compared with the surrounding area of comparable areal density. This supports the theory that redox interactions between Aβ and metals could be at the heart of a pathological feedback system wherein Aβ amyloidosis and oxidative stress promote each other, possibly via Fenton chemistry. © 2005 Elsevier B.V. All rights reserved.
Source Title: Nuclear Instruments and Methods in Physics Research, Section B: Beam Interactions with Materials and Atoms
URI: http://scholarbank.nus.edu.sg/handle/10635/33937
ISSN: 0168583X
DOI: 10.1016/j.nimb.2005.01.078
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