Please use this identifier to cite or link to this item: https://doi.org/10.1016/0006-8993(96)00313-7
Title: Increased iron in the substantia nigra of 6-OHDA induced parkinsonian rats: A nuclear microscopic study
Authors: He, Y.
Lee, T. 
Yuan, S.Y.
Thong, P.S.P.
Watt, F. 
Leong, S.K. 
Shi, C.Y. 
Wong, P.T.H. 
Keywords: 6-Hydroxydopamine
Iron
Parkinson's disease
Rat
Substantia nigra
Issue Date: 1996
Source: He, Y.,Lee, T.,Yuan, S.Y.,Thong, P.S.P.,Watt, F.,Leong, S.K.,Shi, C.Y.,Wong, P.T.H. (1996). Increased iron in the substantia nigra of 6-OHDA induced parkinsonian rats: A nuclear microscopic study. Brain Research 735 (1) : 149-153. ScholarBank@NUS Repository. https://doi.org/10.1016/0006-8993(96)00313-7
Abstract: The trace elemental concentrations, including iron, in the substantia nigra (SN) of a 6-OHDA induced rat model of Parkinson's disease were measured using nuclear microscopy. Only rats that exhibited amphetamine induced rotation of more than 7 turns/min were used. The results showed that the iron levels were significantly increased in the 6-OHDA lesioned SN, compared with the intact contralateral SN, and the SN of normal control rats injected with ascorbic acid, which showed no significant difference in iron levels between injected and non-injected sides. In both 6-OHDA lesioned and ascorbic acid injected SN, there were no alterations in the levels of calcium, magnesium, copper and zinc. In the 6-OHDA lesioned SN there was an almost complete loss of tyrosine hydroxylase positive cells in the SN. These results suggested that the 6-OHDA induced dopaminergic cell death may be related to the increased iron.
Source Title: Brain Research
URI: http://scholarbank.nus.edu.sg/handle/10635/33932
ISSN: 00068993
DOI: 10.1016/0006-8993(96)00313-7
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