Please use this identifier to cite or link to this item: https://doi.org/10.1016/S0306-4522(02)00989-2
Title: Neuroprotection associated with running: Is it a result of increased endogenous neurotrophic factors?
Authors: Ang, E.T.
Ng, Y.K. 
Wong, P.T.H. 
Moochhala, S.
Keywords: ChAT
NGF
p75
Stroke
Treadmill running
Issue Date: 2003
Source: Ang, E.T., Ng, Y.K., Wong, P.T.H., Moochhala, S. (2003). Neuroprotection associated with running: Is it a result of increased endogenous neurotrophic factors?. Neuroscience 118 (2) : 335-345. ScholarBank@NUS Repository. https://doi.org/10.1016/S0306-4522(02)00989-2
Abstract: The possible neuroprotective effect of physical exercise was investigated in rats after middle cerebral artery occlusion (MCAO), a focal stroke model. It was found that physical exercise in the form of a 12-week treadmill running programme reduced the volume of infarction caused by MCAO. At the molecular level, reverse transcription polymerase chain reaction revealed that the runner had increased gene expression for nerve growth factor (NGF) over the nonrunner with or without MCAO. Expression of the NGF receptors, p75, was increased only in the absence of MCAO. In addition, runners showed a significantly higher number of cholinergic neurons, which constitutively expressed p75, in the horizontal diagonal band of Broca. The present findings suggest that neuroprotection after physical exercise may be a result of an increase in an endogenous neurotrophic factor nerve growth factor and the proliferation of its receptive cholinergic neurons. © 2003 IBRO. Published by Elsevier Science Ltd. All rights reserved.
Source Title: Neuroscience
URI: http://scholarbank.nus.edu.sg/handle/10635/33892
ISSN: 03064522
DOI: 10.1016/S0306-4522(02)00989-2
Appears in Collections:Staff Publications

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