Please use this identifier to cite or link to this item:
|Title:||Stonustoxin: A highly potent endothelium-dependent vasorelaxant in the rat|
|Citation:||Low, K.S.Y., Gwee, M.C.E., Yuen, R., Gopalakrishnakone, P. (1993). Stonustoxin: A highly potent endothelium-dependent vasorelaxant in the rat. Toxicon 31 (11) : 1471-1478. ScholarBank@NUS Repository.|
|Abstract:||Stonefish venom has been documented to cause marked hypotension and respiratory difficulties in evenomed animals. Stonustoxin, a lethal protein recently isolated from the venom of the stonefish Synanceja horrida produced hypotension and, at concentrations above 20 μg/kg, death in anaesthetized rats, with no observable effects on nerve-evoked twitches of the tibialis and diaphragm muscles. Stonustoxin (20-160 ng/ml) induced endothelium-dependent relaxations of rat thoracic aortae precontracted with noradrenaline. Higher concentrations induced relaxations followed by contractions. Methylene blue, haemoglobin and the specific NO-synthase inhibitor L-N(G)-nitro arginine methyl ester inhibited stonustoxin-induced relaxations, while the cyclooxygenase inhibitor indomethacin was without effect. The results of the present study show that stonustoxin causes marked vasorelaxation of the rat isolated aorta, which appearss to be due to the release of endothelium-derived relaxing factor (probably nitric oxide or nitric oxide-yielding substances) from the vascular endothelium, and this may be responsible for the in vivo hypotensive and lethal actions of stonustoxin and of stonefish venom.|
|Appears in Collections:||Staff Publications|
Show full item record
Files in This Item:
There are no files associated with this item.
checked on Mar 14, 2018
WEB OF SCIENCETM
checked on May 8, 2018
checked on Jun 2, 2018
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.