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|Title:||Positive and negative modulation by AMPA- and kainate-receptors of striatal kainate injection-induced neuronal loss in rat forebrain|
|Citation:||Zhu, X., Jin, S., Wong, P.T.H., Ng, Y.K., Lee, W.L. (2001). Positive and negative modulation by AMPA- and kainate-receptors of striatal kainate injection-induced neuronal loss in rat forebrain. Brain Research 922 (2) : 293-298. ScholarBank@NUS Repository. https://doi.org/10.1016/S0006-8993(01)03159-6|
|Abstract:||We investigated the roles of ionotropic glutamate receptor subtypes in mediating striatal kainate injection-induced neuronal loss in rat forebrain, using subtype-specific antagonists and histochemical staining. Our study demonstrates that kainate injected unilaterally into the striatum induces a massive neuronal loss in the rat ipsilateral forebrain through activation of kainate receptors and, to a limited extent, a consequent involvement of M-methyl-D-aspartate (NMDA) receptors, whereas activation of α-amino-3-hydroxy-5-methylisoxazol-4-propionate (AMPA) receptors shows a neuroprotective effect. These and previous results suggest that three subtypes of ionotropic glutamate receptors play differential roles in mediating excitatory amino acid (EAA)-induced neurodegeneration. © 2001 Elsevier Science B.V. All rights reserved.|
|Source Title:||Brain Research|
|Appears in Collections:||Staff Publications|
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