Please use this identifier to cite or link to this item: https://doi.org/10.1016/S0006-8993(01)03159-6
Title: Positive and negative modulation by AMPA- and kainate-receptors of striatal kainate injection-induced neuronal loss in rat forebrain
Authors: Zhu, X.
Jin, S.
Wong, P.T.H. 
Ng, Y.K. 
Lee, W.L.
Keywords: CNQX
Cyclothiazide
MK-801
Neurodegeneration
Neuroprotection
Non-NMDA receptor
Issue Date: 2001
Source: Zhu, X., Jin, S., Wong, P.T.H., Ng, Y.K., Lee, W.L. (2001). Positive and negative modulation by AMPA- and kainate-receptors of striatal kainate injection-induced neuronal loss in rat forebrain. Brain Research 922 (2) : 293-298. ScholarBank@NUS Repository. https://doi.org/10.1016/S0006-8993(01)03159-6
Abstract: We investigated the roles of ionotropic glutamate receptor subtypes in mediating striatal kainate injection-induced neuronal loss in rat forebrain, using subtype-specific antagonists and histochemical staining. Our study demonstrates that kainate injected unilaterally into the striatum induces a massive neuronal loss in the rat ipsilateral forebrain through activation of kainate receptors and, to a limited extent, a consequent involvement of M-methyl-D-aspartate (NMDA) receptors, whereas activation of α-amino-3-hydroxy-5-methylisoxazol-4-propionate (AMPA) receptors shows a neuroprotective effect. These and previous results suggest that three subtypes of ionotropic glutamate receptors play differential roles in mediating excitatory amino acid (EAA)-induced neurodegeneration. © 2001 Elsevier Science B.V. All rights reserved.
Source Title: Brain Research
URI: http://scholarbank.nus.edu.sg/handle/10635/33860
ISSN: 00068993
DOI: 10.1016/S0006-8993(01)03159-6
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

3
checked on Dec 6, 2017

WEB OF SCIENCETM
Citations

3
checked on Nov 22, 2017

Page view(s)

101
checked on Dec 17, 2017

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.