Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.brainres.2004.05.055
Title: Expression of glutamate receptors and calcium-binding proteins in the retina of streptozotocin-induced diabetic rats
Authors: Ng, Y.-K. 
Zeng, X.-X.
Ling, E.-A 
Keywords: Calcium-binding protein
Diabetes
Glutamate receptor
Retina
Retina and photoreceptors
Sensory Systems
Issue Date: 2004
Source: Ng, Y.-K.,Zeng, X.-X.,Ling, E.-A (2004). Expression of glutamate receptors and calcium-binding proteins in the retina of streptozotocin-induced diabetic rats. Brain Research 1018 (1) : 66-72. ScholarBank@NUS Repository. https://doi.org/10.1016/j.brainres.2004.05.055
Abstract: This study was aimed to investigate the expression of glutamate receptors and calcium-binding proteins in 1- and 4-month/s (mo) streptozotocin (STZ)-induced diabetic rats. Upregulation of glutamate receptors' [N-methyl-D-aspartate receptor (NMDAR)1 and GluR2/3] immunoreactivities was observed in the ganglion, amacrine and bipolar cells as well as in the inner and outer plexiform layers (IPL and OPL) in 1 mo diabetes and was further enhanced at 4 mo. Immunoreactivity of calcium-binding proteins (calbindin and parvalbumin) was also concomitantly increased. The present results suggest that upregulation of glutamate receptors and calcium-binding proteins may reflect changes of the glutamate and calcium metabolism in the diabetic retina. It is speculated that the above changes in the IPL and OPL may be linked to alteration of synaptic transmission in the diabetic retina. © 2004 Elsevier B.V. All rights reserved.
Source Title: Brain Research
URI: http://scholarbank.nus.edu.sg/handle/10635/33555
ISSN: 00068993
DOI: 10.1016/j.brainres.2004.05.055
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