Please use this identifier to cite or link to this item: https://doi.org/10.1016/S0304-3940(99)00076-2
Title: Microglial reaction in some CNS nuclei following nerves transection in BALB/c and interferon-γ gene knockout mice
Authors: Ng, Y.-K. 
Ling, E.-A. 
Yong, V.-W.
Keywords: Complement type 3 receptor
Gene knock-out mice
Interferon-γ
Microglia
Neurectomy
Issue Date: 1999
Source: Ng, Y.-K., Ling, E.-A., Yong, V.-W. (1999). Microglial reaction in some CNS nuclei following nerves transection in BALB/c and interferon-γ gene knockout mice. Neuroscience Letters 262 (3) : 207-210. ScholarBank@NUS Repository. https://doi.org/10.1016/S0304-3940(99)00076-2
Abstract: The present study was aimed to ascertain if the endogenous IFN-γ is necessary for induction of microglial reaction associated with the CNS neurons after neurectomy of the vagus and hypoglossal nerves in IFN-γ gene knockout mice and BALB/c mice serving as controls. Vigorous microglial reaction as detected by Mac-1 antibody was elicited in the brainstem nuclei in both strains of mice. increased Mac-1 immunoreactivity in microglia was detected as early as 1 day post-operation in the ipsilateral dorsal nucleus of vagus, nucleus ambiguus and the hypoglossal nucleus; a similar feature was observed in the nucleus tractus solitarius bilaterally, Mac-1 immunoreactivity in reactive microglia appeared to increase with survival intervals and was comparable throughout in both strains of mice. It is therefore concluded that endogenous IFN-γ is not responsible for upregulation of complement type 3 receptor immunomolecules in reactive microglia following nerves sectioning.
Source Title: Neuroscience Letters
URI: http://scholarbank.nus.edu.sg/handle/10635/33544
ISSN: 03043940
DOI: 10.1016/S0304-3940(99)00076-2
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