Please use this identifier to cite or link to this item: https://doi.org/10.1016/S0304-3940(98)00941-0
Title: Propentofylline attenuates microglial reaction in the rat spinal cord induced by middle cerebral artery occlusion
Authors: Wu, Y.-P.
Ling, E.-A. 
McRae, A.
Rudolphi, K.
Keywords: Adenosine
Focal cerebral ischaemia
Immunohistochemistry
Lumbar spinal cord
Microglial activation
Propentofylline
Issue Date: 1999
Source: Wu, Y.-P., Ling, E.-A., McRae, A., Rudolphi, K. (1999). Propentofylline attenuates microglial reaction in the rat spinal cord induced by middle cerebral artery occlusion. Neuroscience Letters 260 (1) : 17-20. ScholarBank@NUS Repository. https://doi.org/10.1016/S0304-3940(98)00941-0
Abstract: This study examines the effect of Propentofylline (PPF) on reactive microglia in the lumbar spinal cord in rats following focal cerebral ischaemia produced by permanent occlusion of the middle cerebral artery (MCA). Our results showed that daily treatment of PPF beginning at 24 h after MCA occlusion for 2 or 4 consecutive days markedly suppressed the microglial response as detected immunohistochemically with OX-42. The most dramatic effect was the prevention of transformation of ramified microglia into amoeboidic form as well as formation of perineuronal microglia in close association with the soma of motoneurons. This has greatly amplified the potentiality of PPF used as a neuroprotective drug against microglia-related neuron damage induced by cerebral ischaemia.
Source Title: Neuroscience Letters
URI: http://scholarbank.nus.edu.sg/handle/10635/33541
ISSN: 03043940
DOI: 10.1016/S0304-3940(98)00941-0
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