Please use this identifier to cite or link to this item: https://doi.org/10.1016/S0006-8993(97)01552-7
Title: A light and electron microscopic study of cytoplasmic phospholipase A2and cyclooxygenase-2 in the hippocampus after kainate lesions
Authors: Sandhya, T.L.
Ong, W.Y. 
Horrocks, L.A.
Farooqui, A.A.
Keywords: Arachidonic acid
Cyclooxygenase-2
Excitotoxicity
Glial scar
Hippocampus
Phospholipase A2
Reactive astrocyte
Issue Date: 1998
Citation: Sandhya, T.L., Ong, W.Y., Horrocks, L.A., Farooqui, A.A. (1998). A light and electron microscopic study of cytoplasmic phospholipase A2and cyclooxygenase-2 in the hippocampus after kainate lesions. Brain Research 788 (1-2) : 223-231. ScholarBank@NUS Repository. https://doi.org/10.1016/S0006-8993(97)01552-7
Abstract: The systemic administration of kainate (10 mg/ml) into adult Wistar rats produces seizures and neurodegeneration. We have studied the effect of kainate administration on cPLA2 and COX-2 immunoreactivities after 3 days and 1, 2, 4 and 11 weeks. The cPLA2 immunoreactivity was increased in hippocampal neurons at 1 and 3 days after kainate injection suggesting that PLA2 may be involved in neurodegeneration. Increased cPLA2 and COX-2 immunoreactivities in astrocytes at 1, 2, 4 and 11 weeks after kainate injection indicate an adaptive astrocytic response that may be associated with gliosis.
Source Title: Brain Research
URI: http://scholarbank.nus.edu.sg/handle/10635/33540
ISSN: 00068993
DOI: 10.1016/S0006-8993(97)01552-7
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