Please use this identifier to cite or link to this item:
|Title:||A light and electron microscopic study of cytoplasmic phospholipase A2and cyclooxygenase-2 in the hippocampus after kainate lesions|
|Citation:||Sandhya, T.L., Ong, W.Y., Horrocks, L.A., Farooqui, A.A. (1998). A light and electron microscopic study of cytoplasmic phospholipase A2and cyclooxygenase-2 in the hippocampus after kainate lesions. Brain Research 788 (1-2) : 223-231. ScholarBank@NUS Repository. https://doi.org/10.1016/S0006-8993(97)01552-7|
|Abstract:||The systemic administration of kainate (10 mg/ml) into adult Wistar rats produces seizures and neurodegeneration. We have studied the effect of kainate administration on cPLA2 and COX-2 immunoreactivities after 3 days and 1, 2, 4 and 11 weeks. The cPLA2 immunoreactivity was increased in hippocampal neurons at 1 and 3 days after kainate injection suggesting that PLA2 may be involved in neurodegeneration. Increased cPLA2 and COX-2 immunoreactivities in astrocytes at 1, 2, 4 and 11 weeks after kainate injection indicate an adaptive astrocytic response that may be associated with gliosis.|
|Source Title:||Brain Research|
|Appears in Collections:||Staff Publications|
Show full item record
Files in This Item:
There are no files associated with this item.
checked on Nov 13, 2018
WEB OF SCIENCETM
checked on Oct 17, 2018
checked on Nov 3, 2018
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.