Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.neuroscience.2004.06.055
Title: Distribution of divalent metal transporter-1 in the monkey basal ganglia
Authors: Huang, E.
Ong, W.Y. 
Connor, J.R.
Keywords: astrocytes
blood-brain barrier
divalent metal transporter-1
iron
substantia nigra pars reticulata
Issue Date: 2004
Source: Huang, E., Ong, W.Y., Connor, J.R. (2004). Distribution of divalent metal transporter-1 in the monkey basal ganglia. Neuroscience 128 (3) : 487-496. ScholarBank@NUS Repository. https://doi.org/10.1016/j.neuroscience.2004.06.055
Abstract: An accumulation of iron occurs in the brain with age, and it is thought that this may contribute to the pathology of certain neurodegenerative diseases, including Parkinson's disease. In this study, we elucidated the distribution of divalent metal transporter-1 (DMT1) in the monkey basal ganglia by immunocytochemistry, and compared it with the distribution of ferrous iron in these nuclei by Turnbull's Blue histochemical staining. We observed a general correlation between levels of DMT1, and iron staining. Thus, regions such as the caudate nucleus, putamen, and substantia nigra pars reticulata contained dense staining of DMT1 in astrocytic processes, and were also observed to contain large numbers of ferrous iron granules. The exceptions were the globus pallidus externa and interna, which contained light DMT1 staining, but large numbers of ferrous iron granules. The thalamus, subthalamic nucleus, and substantia nigra pars compacta contained neurons that were lightly stained for DMT1, but few or no iron granules. The high levels of DMT1 expression in some of the nuclei of the basal ganglia, particularly the caudate nucleus, putamen, and substantia nigra pars reticulata, may account for the high levels of iron in these regions. © 2004 IBRO. Published by Elsevier Ltd. All rights reserved.
Source Title: Neuroscience
URI: http://scholarbank.nus.edu.sg/handle/10635/33536
ISSN: 03064522
DOI: 10.1016/j.neuroscience.2004.06.055
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