Please use this identifier to cite or link to this item: https://doi.org/10.1016/S0304-3940(00)01657-8
Title: Hypobaric hypoxia induces Fos and neuronal nitric oxide synthase expression in the paraventricular and supraoptic nucleus in rats
Authors: Luo, Y.
Kaur, C. 
Ling, E.A. 
Keywords: c-fos
Hypobaric hypoxia
Neuronal nitric oxide synthase
Paraventricular nucleus
Supraoptic nucleus
Issue Date: 2000
Source: Luo, Y., Kaur, C., Ling, E.A. (2000). Hypobaric hypoxia induces Fos and neuronal nitric oxide synthase expression in the paraventricular and supraoptic nucleus in rats. Neuroscience Letters 296 (2-3) : 145-148. ScholarBank@NUS Repository. https://doi.org/10.1016/S0304-3940(00)01657-8
Abstract: This study examined the effects of high altitude exposure on neurons in the paraventricular nucleus (PVN) and supraoptic nucleus (SON) of the hypothalamus in adult and neonatal rats. In adult control rats, occasional Fos-like immunoreactive neurons were localized in both the hypothalamic nuclei. A marked increase in Fos positive cells was induced at 1-4 h following altitude exposure but it was reduced to levels comparable to the controls at 24 h. The expression of neuronal nitric oxide synthase (nNOS) immunoreactivity in the PVN and SON followed a similar temporal pattern. The nNOS immunoreactivity, which was constitutively expressed in the hypothalamic neurons in the control rats, was noticeably augmented at 1-4 h, but it was comparable to the controls at 24 h following altitude exposure. In postnatal rats, Fos expression was not detected in the hypothalamic neurons of the controls. Induction of Fos expression was observed in some neurons at 1-4 h following altitude exposure but it was diminished at 24 h. There was no noticeable change in nNOS expression in both the control and altitude exposed postnatal rats; in both instances, it was barely detectable. It is concluded that both the PVN and SON of the adult rats are activated at high altitude exposure and that they may be involved in the regulation of neuroendocrine, cardiovascular and respiratory functions in hypobaric hypoxia. This study has also shown the differential response of the hypothalamus neurons between the two age groups to the hypoxic insult. Our results suggest that the adult neurons are probably more sensitive to the reduced oxygen levels in hypobaric hypoxia, as reflected by the upregulated NOS expression in this age group but not in the postnatal rats. (C) 2000 Elsevier Science Ireland Ltd.
Source Title: Neuroscience Letters
URI: http://scholarbank.nus.edu.sg/handle/10635/33532
ISSN: 03043940
DOI: 10.1016/S0304-3940(00)01657-8
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