Please use this identifier to cite or link to this item: https://doi.org/10.1016/S0304-3940(01)02491-0
Title: Retinoic acid influences the expression of the neuronal regulatory genes Mash-1 and c-ret in the developing rat heart
Authors: Shoba, T.
Dheen, S.T. 
Tay, S.S.W. 
Keywords: Autonomic neurogenesis
Basic helix-loop-helix factors
C-Ret
Cardiac ganglia
Mash-1
Retinoids
Issue Date: 2002
Source: Shoba, T., Dheen, S.T., Tay, S.S.W. (2002). Retinoic acid influences the expression of the neuronal regulatory genes Mash-1 and c-ret in the developing rat heart. Neuroscience Letters 318 (3) : 129-132. ScholarBank@NUS Repository. https://doi.org/10.1016/S0304-3940(01)02491-0
Abstract: We analyzed the expression of neuronal regulatory genes Mash-1 and c-ret by immunohistochemistry and reverse transcriptase-polymerase chain reaction in the developing heart of rat embryos following exogenous retinoic acid (RA) treatment of the pregnant dams. On E12, expression of Mash-1 and c-ret was confined to cells migrating via the common cardinal vein. On E16.5, Mash-1 and c-ret expression were restricted to cardiac ganglia around the great vessels and posterior atrial wall. While Mash-1 expression was down-regulated at birth, that of c-Ret was maintained. RA-treated hearts showed a down-regulation of both Mash-1 and c-Ret at the mRNA as well as at the protein level on E16.5. The present results show that differentiation of cardiac ganglionic cells is affected after RA treatment, by the down-regulation of Mash-1 and c-Ret. © 2002 Elsevier Science Ireland Ltd. All rights reserved.
Source Title: Neuroscience Letters
URI: http://scholarbank.nus.edu.sg/handle/10635/33472
ISSN: 03043940
DOI: 10.1016/S0304-3940(01)02491-0
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