Please use this identifier to cite or link to this item: https://doi.org/10.1016/S0304-3940(03)00927-3
Title: Enhanced expression of transforming growth factor-beta isoforms in the neural tube of embryos derived from diabetic mice exposed to cyclophosphamide
Authors: Lian, Q. 
Samuel, T.S.W.
Dheen, S.T. 
Keywords: Amoeboid microglia
Cyclophosphamide
Diabetic embryos
Neural tube defects
Transforming growth factor-β isoforms
Issue Date: 2003
Source: Lian, Q., Samuel, T.S.W., Dheen, S.T. (2003). Enhanced expression of transforming growth factor-beta isoforms in the neural tube of embryos derived from diabetic mice exposed to cyclophosphamide. Neuroscience Letters 351 (1) : 51-55. ScholarBank@NUS Repository. https://doi.org/10.1016/S0304-3940(03)00927-3
Abstract: We analyzed the expression pattern of transforming growth factor-β isoforms (TGF-β1, TGF-β2 and TGF-β3) in the developing brain of embryos derived from the normal and diabetic mice exposed to cyclophosphamide (CP), a cytotoxic teratogen. The CP-treated diabetic embryos showed significantly more TGF-β1 and TGF-β2 immunoreactive cells in the regions of telencephalon and diencephalon in comparison to that of CP-treated non-diabetic embryos. Moreover, no cells expressing TGF-β isoforms were detectable in the developing brain of normal and diabetic embryos. The mRNA expression levels of TGF-β isoforms were found to be significantly increased in the developing brain of CP-treated diabetic embryos compared to that of CP-treated non-diabetic embryos as measured by quantitative real time reverse transcription-polymerase chain reaction. The enhanced expression levels of TGF-β isoforms appear to be associated with the increased frequency of neural tube defects observed in the diabetic embryos exposed to CP. © 2003 Elsevier Ireland Ltd. All rights reserved.
Source Title: Neuroscience Letters
URI: http://scholarbank.nus.edu.sg/handle/10635/33469
ISSN: 03043940
DOI: 10.1016/S0304-3940(03)00927-3
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