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https://doi.org/10.1016/j.neulet.2006.08.032
DC Field | Value | |
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dc.title | RhoA protein expression correlates positively with degree of malignancy in astrocytomas | |
dc.contributor.author | Yan, B. | |
dc.contributor.author | Peh, B.K. | |
dc.contributor.author | Salto-Tellez, M. | |
dc.contributor.author | Chour, H.H. | |
dc.contributor.author | Lim, C. | |
dc.date.accessioned | 2012-05-29T02:21:50Z | |
dc.date.available | 2012-05-29T02:21:50Z | |
dc.date.issued | 2006 | |
dc.identifier.citation | Yan, B., Peh, B.K., Salto-Tellez, M., Chour, H.H., Lim, C. (2006). RhoA protein expression correlates positively with degree of malignancy in astrocytomas. Neuroscience Letters 407 (2) : 124-126. ScholarBank@NUS Repository. https://doi.org/10.1016/j.neulet.2006.08.032 | |
dc.identifier.issn | 03043940 | |
dc.identifier.uri | http://scholarbank.nus.edu.sg/handle/10635/33190 | |
dc.description.abstract | Astrocytic tumors are the most common intracranial neoplasms. Their prognoses correlate with a conventional morphological grading system that suffers from diagnostic subjectivity and hence, inter-observer inconsistency. A molecular marker that provides an objective reference for classification and prognostication of astrocytic tumors would be useful in diagnostic pathology. RhoA, a GTPase protein involved in cell migration and adhesion, has been shown to be upregulated in a variety of human cancers. Based on direct analysis of clinical materials, our study demonstrates increased expression of RhoA in high-grade astrocytomas. This observation may be relevant to astrocytoma biology and the development of potential therapeutics against high-grade astrocytomas. Of more immediate consequence, utilization of this marker may aid in the routine pathological grading (and hence prognostication) of astrocytomas. © 2006 Elsevier Ireland Ltd. All rights reserved. | |
dc.description.uri | http://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1016/j.neulet.2006.08.032 | |
dc.source | Scopus | |
dc.subject | Astrocytomas | |
dc.subject | Malignancy | |
dc.subject | Protein expression | |
dc.subject | RhoA | |
dc.type | Article | |
dc.contributor.department | NATIONAL UNIVERSITY MEDICAL INSTITUTES | |
dc.contributor.department | PATHOLOGY | |
dc.description.doi | 10.1016/j.neulet.2006.08.032 | |
dc.description.sourcetitle | Neuroscience Letters | |
dc.description.volume | 407 | |
dc.description.issue | 2 | |
dc.description.page | 124-126 | |
dc.description.coden | NELED | |
dc.identifier.isiut | 000241250400007 | |
Appears in Collections: | Staff Publications |
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