Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.ejca.2008.06.044
Title: Potential roles for the PIM1 kinase in human cancer - A molecular and therapeutic appraisal
Authors: Shah, N. 
Yeoh, K.-G. 
Chen, C.S. 
Salto-Tellez, M. 
Thorn, S.
Lilly, M.B.
Keywords: Carcinomas
Kinase
Lymphomas
PIM1
Target inhibitors
Issue Date: 2008
Source: Shah, N., Yeoh, K.-G., Chen, C.S., Salto-Tellez, M., Thorn, S., Lilly, M.B. (2008). Potential roles for the PIM1 kinase in human cancer - A molecular and therapeutic appraisal. European Journal of Cancer 44 (15) : 2144-2151. ScholarBank@NUS Repository. https://doi.org/10.1016/j.ejca.2008.06.044
Abstract: In vitro experiments have shown the PIM1 kinase to have diverse biological roles in cell survival, proliferation and differentiation. In humans, PIM1 is often expressed in both normal and transformed cells. The PIM1 kinase is a true oncogene implicated in early transformation and tumour progression in haematopoietic malignancies and prostate carcinomas. It is associated with aggressive subgroups of lymphoma, is a marker of poor prognosis in prostate carcinomas and has been suggested to have a role in hormone insensitivity of prostate malignancies. PIM1 has a possible role in other carcinomas with 6p21 genomic alterations. On one hand, PIM1 (due to its role in malignancy) appears to be a promising target for drug development programmes but, on the other hand, the complexity of its molecular structure has posed challenges in the development of PIM1 inhibitors. In this review we discuss PIM1 expression in human tissues (including some new data from our laboratory), its role in human malignancies, as well as the possibilities and challenges in the development of target therapy for PIM1. © 2008 Elsevier Ltd. All rights reserved.
Source Title: European Journal of Cancer
URI: http://scholarbank.nus.edu.sg/handle/10635/33180
ISSN: 09598049
DOI: 10.1016/j.ejca.2008.06.044
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

93
checked on Dec 6, 2017

WEB OF SCIENCETM
Citations

87
checked on Nov 17, 2017

Page view(s)

110
checked on Dec 10, 2017

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.