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|Title:||PCBP1 Suppresses the Translation of Metastasis-Associated PRL-3 Phosphatase|
|Citation:||Wang, H., Tan, C.P., Guo, K., Li, J., Lim, S.G., Zeng, Q., Vardy, L.A., Loo, J.M., Zhou, J., Chng, W.J., Ng, S.B., Li, H.X. (2010). PCBP1 Suppresses the Translation of Metastasis-Associated PRL-3 Phosphatase. Cancer Cell 18 (1) : 52-62. ScholarBank@NUS Repository.|
|Abstract:||Overexpression of phosphatase of regenerating liver (PRL)-3 is associated with the progression of diverse human cancers. We show that the overexpression of PRL-3 protein is not directly associated with its transcript levels, indicating the existence of an underlying posttranscriptional regulation. The 5' untranslanted region (UTR) of PRL-3 mRNA possesses triple GCCCAG motifs capable of suppressing mRNA translation through interaction with PolyC-RNA-binding protein 1 (PCBP1), which retards PRL-3 mRNA transcript incorporation into polyribosomes. Overexpression of PCBP1 inhibits PRL-3 expression and inactivates AKT, whereas knockdown of PCBP1 causes upregulation of PRL-3 protein levels, activation of AKT, and promotion of tumorigenesis. An inverse correlation between protein levels of PRL-3 and PCBP1 in human primary cancers supports the clinical relevance. © 2010 Elsevier Inc.|
|Source Title:||Cancer Cell|
|Appears in Collections:||Staff Publications|
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