Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.acthis.2008.07.007
Title: Cofilin immunolabelling correlates with depth of invasion in gastrointestinal endocrine cell tumors
Authors: Yan, B.
Wang, S.
Lee, C.K.
Salto-Tellez, M. 
Kumarasinghe, M.P. 
Yap, C.T. 
Koh, S.
Omar, M.F. 
Keywords: Cofilin
Gastrointestinal endocrine cell tumor
Immunohistochemistry
Issue Date: 2010
Source: Yan, B., Wang, S., Lee, C.K., Salto-Tellez, M., Kumarasinghe, M.P., Yap, C.T., Koh, S., Omar, M.F. (2010). Cofilin immunolabelling correlates with depth of invasion in gastrointestinal endocrine cell tumors. Acta Histochemica 112 (1) : 101-106. ScholarBank@NUS Repository. https://doi.org/10.1016/j.acthis.2008.07.007
Abstract: Gastrointestinal endocrine cell tumors are a heterogeneous population of lesions believed to arise from neuroendocrine cells of the gastrointestinal mucosa. The current classification of these tumors is based on tumor size, microscopic features and clinical evidence of metastasis. Although diagnostic categories generally correlate with prognosis, molecular prognostic markers will be clinically useful adjuncts. Cofilin has been implicated in tumor invasion, and its immunolocalisation was studied in gastrointestinal endocrine cell tumors. The immunolocalisation of cofilin was studied by immunohistochemistry in 34 formalin-fixed, paraffin wax-embedded gastrointestinal endocrine cell tumors using a tissue microarray platform. A significant correlation was found between high cofilin immunolabelling and the depth of invasion (p<0.05). Our findings suggest that cofilin might be useful clinically as a molecular prognostic adjunct in the evaluation of gastrointestinal endocrine cell tumors. © 2008 Elsevier GmbH. All rights reserved.
Source Title: Acta Histochemica
URI: http://scholarbank.nus.edu.sg/handle/10635/33140
ISSN: 00651281
16180372
DOI: 10.1016/j.acthis.2008.07.007
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