Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/32734
Title: Phospholipase A.sub.2-inhibitory peptide with anti-arthritic and neuroprotective activities
Authors: GOPALAKRISHNAKONE, PONNAMPALAM 
THWIN, MAUNG-MAUNG 
ONG, WEI-YI 
SATO, KAZUKI
Issue Date: 13-Feb-2007
Citation: GOPALAKRISHNAKONE, PONNAMPALAM,THWIN, MAUNG-MAUNG,ONG, WEI-YI,SATO, KAZUKI (2007-02-13). Phospholipase A.sub.2-inhibitory peptide with anti-arthritic and neuroprotective activities. ScholarBank@NUS Repository.
Abstract: Peptides that have potent PLA.sub.2-inhibitory activity are disclosed. Homology searches of known PLA inhibitory molecules were used to identify and subsequently design potent peptide molecules that can induce neuroprotective as well as anti-inflammatory effect. These peptides were shown to protect against degeneration of joints in transgenic mouse model prone to arthritis. Protection from kainate-induced excitotoxic neuronal injury was also observed using these peptides. These peptides, their analogs and derivatives have potential as neuroprotective and/or anti-inflammatory agents in a clinical setting.
URI: http://scholarbank.nus.edu.sg/handle/10635/32734
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