Use of des-aspartate-angiotensin I as an anti-cardiac hypertrophic agent

Abstract

The use of des-Aspartate-angiotensin I (Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu) as an anti-cardiac hypertrophic agent is described. The compound, given either intravenously or orally, prevented the development of experimentally-induced cardiac hypertrophy in rats. Its action was dose-dependent and the maximum anti-cardiac hypertrophic effect was obtained at a dose of(i) 180 ng/day when given intravenously, and (ii) 285 .mu.g/day when given orally.