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Title: Investigating the Cytoadherence of Plasmodium Falciparum Infected Red Blood Cells
Authors: ZHANG ROU
Keywords: malaria, dual-pipette technique, cytoadherence, Plasmodium falciparum, PfEMP1, phosphatidylserine
Issue Date: 29-Sep-2011
Citation: ZHANG ROU (2011-09-29). Investigating the Cytoadherence of Plasmodium Falciparum Infected Red Blood Cells. ScholarBank@NUS Repository.
Abstract: Cytoadhesion between malaria-infected red blood cells (iRBCs) and host endothelial cells is closely related to malaria pathogenesis. This thesis studied the adhesion between iRBCs and CSA host receptors. In the first part, the adhesion force of different asexual stages was measured at room temperature. While the adhesion force increased with parasite development, at late schizont stage, it decreased significantly. In the second part, the effect of febrile temperature was assessed, and an increase in the adhesion force was found after the iRBCs were incubated at febrile temperature. The change in the resultant adhesion force was found to be proportional to the surface density of adhesive ligands, and inversely proportional to the cell membrane shear modulus.
Appears in Collections:Ph.D Theses (Open)

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