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Title: Design and Synthesis of Stimuli-Responsive Polymer Based Nanoparticles
Authors: LI MIN
Keywords: Nanoparticle, Stimuli-responsive, Polymer, Self-assembly, Click chemistry, Atom transfer radical polymerization
Issue Date: 4-Aug-2011
Source: LI MIN (2011-08-04). Design and Synthesis of Stimuli-Responsive Polymer Based Nanoparticles. ScholarBank@NUS Repository.
Abstract: There has been a growing interest in the preparation of nanoparticles that can be responsive to the changes of environment in the past decade. Stimuli-responsive polymers have often been used as key materials for the preparation of the responsive nanoparticles, such as in self-assembled copolymer micelles, or as a coating layer or brushes on the surface of solid nanoparticles. The present research work has attempted to develop alternative methods to prepare stimuli-responsive polymer based nanoparticles via three versatile techniques for fabrication of core-shell nanoparticles: self-assembly of amphphilic copolymers, ?graft-to? method and ?graft-from? method. For the self-assembly of amphiphilic copolymers, well-defined ?comb-like? graft copolymers with a fluorescent hydrophobic backbone and stimuli-responsive hydrophilic side chains were first synthesized via free radical polymerization and atom transfer radical polymerization (ATRP). The as-prepared amphiphilic comb-like graft copolymers can be self-assembled in aqueous medium into nanoparticles with controlled morphology, size and fluorescent intensity. For the ?graft-to? approach, temperature- and pH-responsive fluorescent copolymers were synthesized via ATRP and subsequently grafted to the surface of mesoporous silica nanospheres (MSNs) via ?click chemistry?, giving rise to well-defined pH- and temperature-responsive fluorescent MSNs. For the ?graft-from? approach, the superparamagnetic and pH-responsive metal/organic hybrid nanoparticles were prepared via Michael addition reaction and click chemistry. The resulted hybrid nanoparticles consist of a Fe3O4 nanocore, a silica inner shell and pH-responsive dendrimer outer shell. The as-prepared stimuli-responsive polymer based nanoparticles in this research can provide potential applications such as optical sensors, controlled drug storage and delivery, cell imaging and protein recognition.
Appears in Collections:Ph.D Theses (Open)

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