Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/32479
Title: Design and Synthesis of Stimuli-Responsive Polymer Based Nanoparticles
Authors: LI MIN
Keywords: Nanoparticle, Stimuli-responsive, Polymer, Self-assembly, Click chemistry, Atom transfer radical polymerization
Issue Date: 4-Aug-2011
Source: LI MIN (2011-08-04). Design and Synthesis of Stimuli-Responsive Polymer Based Nanoparticles. ScholarBank@NUS Repository.
Abstract: There has been a growing interest in the preparation of nanoparticles that can be responsive to the changes of environment in the past decade. Stimuli-responsive polymers have often been used as key materials for the preparation of the responsive nanoparticles, such as in self-assembled copolymer micelles, or as a coating layer or brushes on the surface of solid nanoparticles. The present research work has attempted to develop alternative methods to prepare stimuli-responsive polymer based nanoparticles via three versatile techniques for fabrication of core-shell nanoparticles: self-assembly of amphphilic copolymers, ?graft-to? method and ?graft-from? method. For the self-assembly of amphiphilic copolymers, well-defined ?comb-like? graft copolymers with a fluorescent hydrophobic backbone and stimuli-responsive hydrophilic side chains were first synthesized via free radical polymerization and atom transfer radical polymerization (ATRP). The as-prepared amphiphilic comb-like graft copolymers can be self-assembled in aqueous medium into nanoparticles with controlled morphology, size and fluorescent intensity. For the ?graft-to? approach, temperature- and pH-responsive fluorescent copolymers were synthesized via ATRP and subsequently grafted to the surface of mesoporous silica nanospheres (MSNs) via ?click chemistry?, giving rise to well-defined pH- and temperature-responsive fluorescent MSNs. For the ?graft-from? approach, the superparamagnetic and pH-responsive metal/organic hybrid nanoparticles were prepared via Michael addition reaction and click chemistry. The resulted hybrid nanoparticles consist of a Fe3O4 nanocore, a silica inner shell and pH-responsive dendrimer outer shell. The as-prepared stimuli-responsive polymer based nanoparticles in this research can provide potential applications such as optical sensors, controlled drug storage and delivery, cell imaging and protein recognition.
URI: http://scholarbank.nus.edu.sg/handle/10635/32479
Appears in Collections:Ph.D Theses (Open)

Show full item record
Files in This Item:
File Description SizeFormatAccess SettingsVersion 
LiM.pdf7.81 MBAdobe PDF

OPEN

NoneView/Download

Page view(s)

285
checked on Dec 11, 2017

Download(s)

769
checked on Dec 11, 2017

Google ScholarTM

Check


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.