Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/32466
Title: Effects of Ovariectomy, Anabolic and Anti-resorptive Treatments and their Combined Effects on Bone Micro-architecture Assessed using Micro-CT
Authors: CHAN YONG HOOW
Keywords: micro-ct,micro-architecture,anti-resorptive,anabolic,ovariectomy,osteoporosis
Issue Date: 12-Aug-2011
Source: CHAN YONG HOOW (2011-08-12). Effects of Ovariectomy, Anabolic and Anti-resorptive Treatments and their Combined Effects on Bone Micro-architecture Assessed using Micro-CT. ScholarBank@NUS Repository.
Abstract: Osteoporosis is becoming a major health concern with the rapidly graying population. Predicting fracture likelihood using current BMD measurement is inadequate as micro-architectural changes in the trabecular bone is not taken into account. It is useful to quantitatively study these micro-architectural changes in addition to BMD in order to understand the progression of osteoporosis and to assess how anabolic (PTH), anti-resorptive (bisphosphonates) and their combined therapeutic effects reduce the rate of bone loss. Computational morphological analyses based on several bone indicators from micro-CT in-vitro scans of rat tibias from the rat osteoporosis model were performed during the drug trials. 3-dimensional rendering of internal trabecular structures were used to visualize drug efficacies. Statistical analyses were employed to identify significant improvements from anabolic and anti-resorptive treatments. Results showed effective early intervention with either anabolic or anti-resorptive drugs and there is no significant antagonistic effect when using both therapies concurrently.
URI: http://scholarbank.nus.edu.sg/handle/10635/32466
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