Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/32384
Title: DEVELOPMENTAL AND TRANSCRIPTOMIC STUDY OF THE ZEBRAFISH SWIMBLADDER
Authors: ZHENG WEILING
Keywords: zebrafish,swimbladder,fgf,transcriptome,lung,homology
Issue Date: 19-Aug-2011
Source: ZHENG WEILING (2011-08-19). DEVELOPMENTAL AND TRANSCRIPTOMIC STUDY OF THE ZEBRAFISH SWIMBLADDER. ScholarBank@NUS Repository.
Abstract: The swimbladder is a unique organ in fish for buoyancy regulation. It has been postulated as a homolog of the tetrapod lung, but the molecular evidence is scare. In this study, I intended to provide evidence on the evolutionary homology from both developmental and transcriptomic aspects. I identified homologous expression of Fgf signaling ligand and receptor, and discovered both conserved and divergent function of Fgf signaling in swimbladder development comparing to lung development. In the screening for molecules expressing in developing swimbladder, I found that the swimbladder showed much less complex gene expression profile, which might explain the simplicity of the swimbladder structure comparing to the lung. I also employed RNA-seq technology to study the adult zebrafish swimbladder transcriptome, which revealed unique aspects of the swimbladder transcriptome and established correlation between the zebrafish swimbladder and the mammalian lung.
URI: http://scholarbank.nus.edu.sg/handle/10635/32384
Appears in Collections:Ph.D Theses (Open)

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