Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/32303
Title: Synthesis of Fluorescent Anti-Malarial Drug Probes And Evaluation Within Plasmodium Falciparum
Authors: KUNAL HEMANT MAHAJAN
Keywords: Synthesis, Plasmodium Falciparum, Drug Probes, Medicinal
Issue Date: 15-Aug-2011
Source: KUNAL HEMANT MAHAJAN (2011-08-15). Synthesis of Fluorescent Anti-Malarial Drug Probes And Evaluation Within Plasmodium Falciparum. ScholarBank@NUS Repository.
Abstract: On World Malaria Day April 2010, impetus has been towards reducing Malaria burden in 2010 to half as compared to the year 2000 levels and to achieve eradication of malaria by 2015 through progressive elimination methods1. These methods rely heavily upon effective and efficient diagnosis of the parasite making it a crucial step towards early identification, control and subsequent elimination of the disease. The gold standard for malaria diagnosis still continues to be optical microscopy, although it has severe limitations due to its ease of availability, labor intensive process and need for highly skilled technicians. The emergence of chloroquine resistant strains in 1957and the further discovery of multi-drug resistant strains (MDRSs) and recent Artemisinin resistant strains3 in 2009 along the Thai-Cambodian border, has been a cause of grave concern. The current diagnostic techniques do not address the above need for differentiating sensitive vs resistant strains of the parasite, which would be an important factor in determining the clinical administration of the effective drug. My current thesis involving ¿Synthesis of fluorescent anti-malarial drug probes and evaluation within plasmodium falciparum¿ addresses the above requirement for a robust, fast, sensitive, & portable diagnostic technique for determination of drug resistant Plasmodium falciparum strains within patient blood samples. The probes designed would help in reliable data collection and administration of the appropriate drug dosage. The thesis discusses the drug design rationale, synthesis and results of the application of the probes in (1) malaria diagnosis (in collaboration with Dr. Kevin Tan), (2) cancer studies (in collaboration with National Cancer Institute, USA) and (3) bio-imaging studies on macrophages (studies done by myself in collaboration with Dr. Kevin Tan). The probes are mainly designed on chloroquine and artemisinin analogues, which are the preliminary drugs administered for the treatment of malaria. The probes tested on Plasmodium falciparum & mammalian cell lines established their lysosomotropic nature thus providing potential insight into the pathway within the parasite and macrophages. The future lies in utilizing the concept of drug probes or ¿Medicinal Probes¿ towards evaluation and bio-imaging studies on various diseases.
URI: http://scholarbank.nus.edu.sg/handle/10635/32303
Appears in Collections:Master's Theses (Open)

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