Please use this identifier to cite or link to this item:
https://doi.org/10.1016/0009-3084(92)90067-Y
DC Field | Value | |
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dc.title | Effect of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and its toxic metabolites on the physicochemical property of the liposomal membrane in relation to their cytochrome P-450 inhibition | |
dc.contributor.author | Das, N.P. | |
dc.contributor.author | Shahi, G.S. | |
dc.contributor.author | Moochhala, S.M. | |
dc.contributor.author | Sato, T. | |
dc.contributor.author | Sunamoto, J. | |
dc.date.accessioned | 2012-04-02T07:54:43Z | |
dc.date.available | 2012-04-02T07:54:43Z | |
dc.date.issued | 1992 | |
dc.identifier.citation | Das, N.P., Shahi, G.S., Moochhala, S.M., Sato, T., Sunamoto, J. (1992). Effect of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and its toxic metabolites on the physicochemical property of the liposomal membrane in relation to their cytochrome P-450 inhibition. Chemistry and Physics of Lipids 62 (3) : 303-310. ScholarBank@NUS Repository. https://doi.org/10.1016/0009-3084(92)90067-Y | |
dc.identifier.issn | 00093084 | |
dc.identifier.uri | http://scholarbank.nus.edu.sg/handle/10635/32254 | |
dc.description.abstract | The effects of the neurotoxin MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) and its toxic metabolites MPDP+ (1-methyl-4-phenyl-2,3-dihydropryridinium) and MPP+ (1-methyl-4-phenylpyridinium) on liposomal membrane were assessed using fluorescence-polarization and carboxyfluorescein leakage studies as well as in biological membrane preparations. Of the three compounds, MPTP was found to cause the greatest perturbation of membrane followed by MPDP+ and then MPP+. The ability of the three toxins to inhibit cytochrome P-450 enzyme activity (a microsomal membrane-bound enzyme system) was also studied and their relative potency was again found to be MPTP > MPDP+ > MPP+. The changes in the physicochemical property of the liposomal membrane can be related to the ability of the neurotoxins's ability to inhibit cytochrome P-450 activity. | |
dc.description.uri | http://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1016/0009-3084(92)90067-Y | |
dc.source | Scopus | |
dc.subject | Changes in membrane fluidity | |
dc.subject | Cytochrome P-450 inhibition | |
dc.subject | MPDP+(1-methyl-4-phenyl-2,3-dihydropyridinium) | |
dc.subject | MPP+(1-methyl-4-phenylpyridinium) | |
dc.subject | MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) | |
dc.type | Article | |
dc.contributor.department | PHARMACOLOGY | |
dc.contributor.department | BIOCHEMISTRY | |
dc.description.doi | 10.1016/0009-3084(92)90067-Y | |
dc.description.sourcetitle | Chemistry and Physics of Lipids | |
dc.description.volume | 62 | |
dc.description.issue | 3 | |
dc.description.page | 303-310 | |
dc.description.coden | CPLIA | |
dc.identifier.isiut | A1992JY46400011 | |
Appears in Collections: | Staff Publications |
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