Please use this identifier to cite or link to this item: https://doi.org/10.1016/0009-3084(92)90067-Y
Title: Effect of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and its toxic metabolites on the physicochemical property of the liposomal membrane in relation to their cytochrome P-450 inhibition
Authors: Das, N.P. 
Shahi, G.S.
Moochhala, S.M. 
Sato, T.
Sunamoto, J.
Keywords: Changes in membrane fluidity
Cytochrome P-450 inhibition
MPDP+(1-methyl-4-phenyl-2,3-dihydropyridinium)
MPP+(1-methyl-4-phenylpyridinium)
MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine)
Issue Date: 1992
Source: Das, N.P., Shahi, G.S., Moochhala, S.M., Sato, T., Sunamoto, J. (1992). Effect of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and its toxic metabolites on the physicochemical property of the liposomal membrane in relation to their cytochrome P-450 inhibition. Chemistry and Physics of Lipids 62 (3) : 303-310. ScholarBank@NUS Repository. https://doi.org/10.1016/0009-3084(92)90067-Y
Abstract: The effects of the neurotoxin MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) and its toxic metabolites MPDP+ (1-methyl-4-phenyl-2,3-dihydropryridinium) and MPP+ (1-methyl-4-phenylpyridinium) on liposomal membrane were assessed using fluorescence-polarization and carboxyfluorescein leakage studies as well as in biological membrane preparations. Of the three compounds, MPTP was found to cause the greatest perturbation of membrane followed by MPDP+ and then MPP+. The ability of the three toxins to inhibit cytochrome P-450 enzyme activity (a microsomal membrane-bound enzyme system) was also studied and their relative potency was again found to be MPTP > MPDP+ > MPP+. The changes in the physicochemical property of the liposomal membrane can be related to the ability of the neurotoxins's ability to inhibit cytochrome P-450 activity.
Source Title: Chemistry and Physics of Lipids
URI: http://scholarbank.nus.edu.sg/handle/10635/32254
ISSN: 00093084
DOI: 10.1016/0009-3084(92)90067-Y
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