Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.brainres.2005.03.016
Title: Simvastatin reverses the downregulation of dopamine D1 and D2 receptor expression in the prefrontal cortex of 6-hydroxydopamine-induced Parkinsonian rats
Authors: Wang, Q.
McLachlan, C.
Wong, P.T.-H. 
Wang, P.H. 
Keywords: 6-OHDA lesion
Dopamine D1and D2receptors
Downregulation
Parkinson's disease (PD)
Simvastatin, hydroxymethylglutaryl-coenzyme A reductase inhibitor
Upregulation
Issue Date: 2005
Citation: Wang, Q., McLachlan, C., Wong, P.T.-H., Wang, P.H. (2005). Simvastatin reverses the downregulation of dopamine D1 and D2 receptor expression in the prefrontal cortex of 6-hydroxydopamine-induced Parkinsonian rats. Brain Research 1045 (1-2) : 229-233. ScholarBank@NUS Repository. https://doi.org/10.1016/j.brainres.2005.03.016
Abstract: Sprague-Dawley rats with unilateral lesion of the medial forebrain bundle by 6-hydroxydopamine showed marked decrease in the expression of dopamine D 1 and D2 receptors in the prefrontal cortex. Simvastatin (10 mg/kg/day for 4 weeks) restored receptor expression to control levels. Given the association of dopaminergic dysfunction in the prefrontal cortex and cognitive deficits in Parkinson's disease, these findings may have implication in the treatment of cognitive decline in advanced Parkinson's disease. © 2005 Elsevier B.V. All rights reserved.
Source Title: Brain Research
URI: http://scholarbank.nus.edu.sg/handle/10635/32248
ISSN: 00068993
DOI: 10.1016/j.brainres.2005.03.016
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