Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.neulet.2004.01.027
Title: Analysis of strain difference in behavior to Cholecystokinin (CCK) receptor mediated drugs in PVG hooded and Sprague-Dawley rats using elevated plus-maze test apparatus
Authors: Farook, J.M.
Zhu, Y.Z. 
Wang, Q.
Wong, P.T.-H. 
Moochhala, S.M. 
Lee, L.
Keywords: Cholecystokinin
Plus maze test apparatus
Sprague-Dawley rats
Issue Date: 2004
Source: Farook, J.M., Zhu, Y.Z., Wang, Q., Wong, P.T.-H., Moochhala, S.M., Lee, L. (2004). Analysis of strain difference in behavior to Cholecystokinin (CCK) receptor mediated drugs in PVG hooded and Sprague-Dawley rats using elevated plus-maze test apparatus. Neuroscience Letters 358 (3) : 215-219. ScholarBank@NUS Repository. https://doi.org/10.1016/j.neulet.2004.01.027
Abstract: This study investigated the behavioral mechanisms underlying the anxiogenic, or anxiolytic mediated effects of CCK2 receptor mediated agonist (CCK-4) and antagonist drugs (LY225910, LY288513, CR2945) in PVG hooded and Sprague-Dawley (SD) rats using the elevated plus maze test apparatus. In addition, the effects of a CCK1 antagonist (CR1409) were investigated for its possible mediation in anxiety behavior between PVG hooded and SD rats. PVG hooded rats treated with CCK-4, decreased the time spent in the open arm and increased the time spent in the closed arm and correspondingly showed increase in the number of entries in the open arms while the number of entries in closed arm was insignificant, whereas SD rats decreased the time spent in the closed arm, while other parameters remained insignificant. PVG hooded rats administered with various CCK2 antagonists (LY225910, LY288513, and CR2945) significantly increased the time spent in the open arm and correspondingly decreased the time spent in the closed arm, while the number of entries in the open or closed arm was insignificant, in contrast, SD rats failed to show any reliable significance. PVG hooded rats administered with the CCK1 antagonist (CR1409), failed to show any reliable significance, in contrast, SD rats significantly increased the time spent in the open arm. The strain differences observed in this study suggests that CCK plays mainly as a neuromodulator, in which the various CCK2 antagonists may not affect baseline anxiety state, but instead they modulate heightened states of anxiety through differential effects of CCK 1/CCK2 receptors. © 2004 Elsevier Ireland Ltd. All rights reserved.
Source Title: Neuroscience Letters
URI: http://scholarbank.nus.edu.sg/handle/10635/32191
ISSN: 03043940
DOI: 10.1016/j.neulet.2004.01.027
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

12
checked on Dec 11, 2017

WEB OF SCIENCETM
Citations

12
checked on Dec 11, 2017

Page view(s)

146
checked on Dec 9, 2017

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.