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Title: Comparison of cardioprotective effects using ramipril and DanShen for the treatment of acute myocardial infarction in rats
Authors: Ji, X.
Tan, B.K.-H. 
Zhu, Y.Z. 
Linz, W.
Zhu, Y.C.
Keywords: Acute myocardial infarction
Infarct size
Salvia miltiorrhiza
Issue Date: 2003
Citation: Ji, X., Tan, B.K.-H., Zhu, Y.Z., Linz, W., Zhu, Y.C. (2003). Comparison of cardioprotective effects using ramipril and DanShen for the treatment of acute myocardial infarction in rats. Life Sciences 73 (11) : 1413-1426. ScholarBank@NUS Repository.
Abstract: In the present study, we compared cardioprotective effects of DanShen (an extract from Salvia miltiorrhiza) and the angiotensin-converting enzyme inhibitor, ramipril, in rats. With both treatment regimens, DanShen- and ramipril similar effects were observed: (1) a higher survival rate, (2) a significant reduction of infarct size, (3) significantly lower ratios of heart weight to the body weight as well as the left and right ventricular weights to body weight. DanShen showed some unique effects in the following aspects: (1) higher activities of antioxidant defense enzymes such as superoxide dismutase (SOD), catalase (CAT), glutatione perioxidase (GSH-Px) and glutathione S-transferase (GST) in the liver of rats with acute myocardial infarction (AMI), (2) lower myocardial and hepatic TBARS values; (3) augmented VEGF mRNA expressions in the non-ischemic parts of rat hearts with AMI. These results were consistent with the findings of a slight increase in myocardial capillary density and the special distribution pattern of coronary blood vessels in DanShen-treated rats. © 2003 Elsevier Science Inc. All rights reserved.
Source Title: Life Sciences
ISSN: 00243205
DOI: 10.1016/S0024-3205(03)00432-6
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