Please use this identifier to cite or link to this item: https://doi.org/10.1016/0014-2999(94)90714-5
Title: Novel central action of des-Asp-angiotensin I
Authors: Sim, M.K. 
Radhakrishnan, R.
Keywords: Angiotensin III
des-Asp-Angiotensin I
Spontaneously hypertensive rat (SHR)
Issue Date: 1994
Source: Sim, M.K., Radhakrishnan, R. (1994). Novel central action of des-Asp-angiotensin I. European Journal of Pharmacology 257 (1-2). ScholarBank@NUS Repository. https://doi.org/10.1016/0014-2999(94)90714-5
Abstract: Intracerebroventricularly administered des-Asp-angiotensin I, when prevented from degradation by prior administration of captopril, attenuated dose-dependently the central pressor actions of angiotensin II and angiotensin III in the spontaneously hypertensive (SHR) and Wistar Kyoto (WKY) rats. This finding is the first demonstration of an intrinsic action of des-Asp-angiotensin I and, together with earlier finding of its increased production in the hypothalamus of the spontaneously hypertensive rat, may support the suggestion that the nonapeptide is a functional angiotensin that regulates the pressor action of angiotensin II and angiotensin III in the brain.
Source Title: European Journal of Pharmacology
URI: http://scholarbank.nus.edu.sg/handle/10635/32170
ISSN: 00142999
DOI: 10.1016/0014-2999(94)90714-5
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