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Title: Effects of des-aspartate-angiotensin I on neointima growth and cardiovascular hypertrophy
Authors: Kwoon, S.M. 
Ru, T.F.
Guang, X.X.
Keywords: Arteriosclerosis
Cardiac hypertrophy
Des-aspartate-angiotensin I
Issue Date: 2004
Citation: Kwoon, S.M., Ru, T.F., Guang, X.X. (2004). Effects of des-aspartate-angiotensin I on neointima growth and cardiovascular hypertrophy. Regulatory Peptides 117 (3) : 213-217. ScholarBank@NUS Repository.
Abstract: The in vitro anti-hypertrophic and hyperplastic actions of des-aspartate-angiotensin I (DAA-I) on cultured cardiovascular cells have been demonstrated in earlier experiments. The present study investigated its effects on the development of neointima in balloon catheter-injured carotid artery of the Sprague-Dawley (SD) rat and the development of cardiovascular hypertrophy in the spontaneously hypertensive rat. Treatment with i.v. DAA-I for 14 days post-injury dose-dependently attenuated the development of neointima. The maximum effect was obtained at 34 pmol/kg/day. The data support the possibility that endogenous angiotensins could inhibit neointima growth. This opens up avenues for their therapeutic elevation in combating neointima-related restenosis of which current drugs are not fully effective in suppressing. Five-week-old pre-hypertensive SHR, when orally administered with a dose of 769 nmol/kg/day DAA-I for a duration of 47 weeks, showed significant reduction in the development of cardiac and vascular hypertrophy compared to the untreated controls. Similar treatment with DAA-I had no effect on the Wistar Kyoto rats. The present findings support the contention that, besides angiotensin II, other endogenous angiotensins are also involved in the regulation and/or pathophysiology of the cardiovascular system. © 2003 Elsevier B.V. All rights reserved.
Source Title: Regulatory Peptides
ISSN: 01670115
DOI: 10.1016/j.regpep.2003.10.030
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