Please use this identifier to cite or link to this item: https://doi.org/10.1016/0014-2999(95)00461-S
Title: Effects of des-Asp-angiotensin I on the electrically stimulated contraction of the rabbit pulmonary artery
Authors: Sim, M.K. 
Soh, K.S.
Keywords: des-Asp-angiotensin I
losartan
PD123319
pulmonary artery, rabbit
superfusion
transmural stimulation
Issue Date: 1995
Source: Sim, M.K., Soh, K.S. (1995). Effects of des-Asp-angiotensin I on the electrically stimulated contraction of the rabbit pulmonary artery. European Journal of Pharmacology 284 (1-2) : 215-219. ScholarBank@NUS Repository. https://doi.org/10.1016/0014-2999(95)00461-S
Abstract: In the presence of 3 x 10-6 M captopril, 5 x 10-7 M des-Asp-angiotensin I was found to inhibit the electrically (1 and 2 Hz) induced contraction of the rabbit pulmonary artery but had no significant effect on the noradrenaline-stimulated contraction. 2.8 x 10-6 M indomethacin and 10-6 M losartan but not 10-6 M (S) 1-{[4-(dimethylamino)-3-methylphenyl]methyl}-5(diphenylacetyl)-4,5,6 ,7-tetrahydro-1H-imidazo{4,5-c]pyridine-6-carboxylic acid, ditrifluoroacetate, dihydrate (PD123319) attenuated the inhibition. The inhibition of the electrically stimulated contraction by 5 x 10-7 M des-Asp-angiotensin I coincided with a significant drop in the accompanying evoked 3H overflow from re-uptaken [3H]noradrenaline. The results indicate that des-Asp-angiotensin I acts presynaptically on a subtype of angiotensin receptor that involves the release of prostaglandin(s). In addition, this receptor subtype is susceptible to blockade by angiotensin AT1- but not AT2-specific receptor antagonists. It was suggested that this receptor subtype is identifiable with the recently described angiotensin AT(1B) receptor subtype found in the brain, pituitary and adrenal glomerulosa. These findings demonstrated a direct action of sub-micromolar concentrations of des-Asp-angiotensin I on a blood vessel and indicate that the nonapeptide is an active angiotensin per se.
Source Title: European Journal of Pharmacology
URI: http://scholarbank.nus.edu.sg/handle/10635/32165
ISSN: 00142999
DOI: 10.1016/0014-2999(95)00461-S
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

16
checked on Dec 11, 2017

WEB OF SCIENCETM
Citations

16
checked on Dec 11, 2017

Page view(s)

139
checked on Dec 9, 2017

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.