Please use this identifier to cite or link to this item:
|Title:||Reduction of infarct size by orally administered des-aspartate-angiotensin I in the ischemic reperfused rat heart|
|Authors:||Wen, Q. |
|Source:||Wen, Q., Sim, M.-K., Tang, F.-R. (2004). Reduction of infarct size by orally administered des-aspartate-angiotensin I in the ischemic reperfused rat heart. Regulatory Peptides 120 (1-3) : 149-153. ScholarBank@NUS Repository. https://doi.org/10.1016/j.regpep.2004.03.003|
|Abstract:||Occlusion of the left main coronary artery for 45 min caused sizable infarct scaring of the left ventricular wall in the rat heart at 14 days post-reperfusion. Daily oral administration of des-aspartate-angiotensin I (DAA-I) for 14 days attenuated the area of the infarct scar and transmurality. The attenuation was dose-dependent and biphasic; maximum effective dose was 1524 nmol/kg, and doses higher than this were progressively inactive. The exact mechanism of the biphasic attenuation is not known, and receptor down-regulation by internalization, which has been implicated in a similar biphasic nature for the anticardiac hypertrophic action of DAA-I, could be a likely cause. Indomethacin (101 μmol/kg, i.p.), administered sequentially after the daily oral dose of DAA-I (1524 nmol/kg), completely inhibited the attenuation at 14 days post-reperfusion, indicating that prostaglandins may be involved in transducing the attenuation. The present findings support earlier indications that DAA-I exerts protective actions in cardiovascular pathologies in which angiotensin II is implicated. It is suggested that DAA-I exerts the cardioprotective action by acting on the same indomethacin-sensitive angiotensin AT1 receptor. Although similar array of protective actions are also seen with another endogenous angiotensin, angiotensin-(1-7), the present findings demonstrate for the first time the ability of an endogenous angiotensin to reduce the infarct size of an ischemic-reperfusion injured rat heart. © 2004 Elsevier B.V. All rights reserved.|
|Source Title:||Regulatory Peptides|
|Appears in Collections:||Staff Publications|
Show full item record
Files in This Item:
There are no files associated with this item.
checked on Jan 17, 2018
WEB OF SCIENCETM
checked on Dec 11, 2017
checked on Jan 22, 2018
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.