Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.neulet.2003.11.072
Title: Cholecystokinin-B receptor gene expression in cerebellum, pre-frontal cortex and cingulate gyrus and its association with suicide
Authors: Sherrin, T.
Heng, K.Y.C.
Zhu, Y.Z. 
Tan, C.H. 
Tang, Y.M.
Lau, G.
Keywords: Cerebellum
Cholecystokinin-B (CCKB)
Cingulate gyrus
Gene expression
Pre-frontal cortex
RT-PCR
Suicide
Issue Date: 2004
Source: Sherrin, T., Heng, K.Y.C., Zhu, Y.Z., Tan, C.H., Tang, Y.M., Lau, G. (2004). Cholecystokinin-B receptor gene expression in cerebellum, pre-frontal cortex and cingulate gyrus and its association with suicide. Neuroscience Letters 357 (2) : 107-110. ScholarBank@NUS Repository. https://doi.org/10.1016/j.neulet.2003.11.072
Abstract: Suicide is a complex behaviour. Genetic and environmental factors are implicated in suicide. Both factors require genes to exert their effects. One gene hypothesized to be involved in the pathophysiology of suicide is cholecystokinin. Alterations in cholecystokinin receptor binding have been reported to be significant in young suicide victims as compared to matched controls in the frontal and cingulate cortex. In this study we report the Cholecystokinin-B gene expression using RT-PCR, between suicide completers [(N=10); mean age 37.2±12 years] and control subjects [(N=10); mean age 37.6±11.9 years]. Cholecystokinin-B gene expression was significantly higher in the cerebellum (P=0.006), cingulate gyrus (P=0.024) and pre-frontal cortex (P=0.017) of suicide completers when compared to their age and sex-matched controls. © 2003 Published by Elsevier Ireland Ltd.
Source Title: Neuroscience Letters
URI: http://scholarbank.nus.edu.sg/handle/10635/32122
ISSN: 03043940
DOI: 10.1016/j.neulet.2003.11.072
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