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|Title:||Pre- and/or post-synaptic localisation of metabotropic glutamate receptor 1α (mGluR1α) and 2/3 (mGluR2/3) in the rat spinal cord|
Pre- and post-synaptic localisation
|Source:||Tang, F.R., Sim, M.K. (1999). Pre- and/or post-synaptic localisation of metabotropic glutamate receptor 1α (mGluR1α) and 2/3 (mGluR2/3) in the rat spinal cord. Neuroscience Research 34 (2) : 73-78. ScholarBank@NUS Repository. https://doi.org/10.1016/S0168-0102(99)00035-8|
|Abstract:||Using immunocytochemical techniques (light and electron microscopy), weakly stained metabotropic glutamate receptor (mGluR) 1α immunoreactivity was detected in lamina I of the rat spinal cord. Immunoreactivity for mGluR2/3 was almost undetectable in this lamina and outer lamina II. In lamina II, there was mGluR1α immunoreactivity. Strongly stained mGluR2/3 was seen in the inner layer of lamina II and the dorsal part of lamina III. In laminae III-X, weakly to moderately stained mGluR1α immunoreactive product was demonstrated. Similar staining for mGluR2/3 was also seen in lamina III-VI and in lamina X, but mGluR2/3 immunoreactivities were few in lamina VII-IX. With electron microscopy, mGluR1α immunoreactivity was seen in neuronal cell body and dendrites in lamina II of the dorsal horn. In the lateral and ventral horns, only dendrites of neurons were mGluR1α immunopositive. Some mGluR2/3 immunopositive dendrites were demonstrated in lamina II of the dorsal horn, lateral and ventral horns. In the ventral horn, mGluR2/3 immunopositive axon and axon terminals were demonstrated. Some mGluR2/3 immunopositive astrocytes were also demonstrated in the three areas and their strongly stained processes wrapped around neuronal cell bodies and synapses. Copyright (C) 1999 Elsevier Science Ireland Ltd.|
|Source Title:||Neuroscience Research|
|Appears in Collections:||Staff Publications|
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