Please use this identifier to cite or link to this item:
https://doi.org/10.1016/S0378-4347(97)00005-4
DC Field | Value | |
---|---|---|
dc.title | Determination of aminopeptidase X activity in tissues of normo- and hypertensive rats by capillary electrophoresis | |
dc.contributor.author | Sim, M.K. | |
dc.contributor.author | Lim, B.C. | |
dc.date.accessioned | 2012-04-02T07:42:13Z | |
dc.date.available | 2012-04-02T07:42:13Z | |
dc.date.issued | 1997 | |
dc.identifier.citation | Sim, M.K., Lim, B.C. (1997). Determination of aminopeptidase X activity in tissues of normo- and hypertensive rats by capillary electrophoresis. Journal of Chromatography B: Biomedical Applications 697 (1-2) : 259-262. ScholarBank@NUS Repository. https://doi.org/10.1016/S0378-4347(97)00005-4 | |
dc.identifier.issn | 15726495 | |
dc.identifier.uri | http://scholarbank.nus.edu.sg/handle/10635/32115 | |
dc.description.abstract | Aminopeptidase X, an enzyme that degrades angiotensin I to des-asp-angiotensin I, was determined in the lung, liver, kidney, plasma, endothelium and aortic smooth muscle of the spontaneously hypertensive rat (SHR) and its normotensive control, the Wistar Kyoto rat (WKY). The enzyme activity in the lung, kidney, plasma and endothelium of the SHR was elevated and this supports an earlier suggestion that in certain critical tissues of the SKR, the degradation of angiotensin I is shunted in favour of the des-asp-angiotensin I pathway. In these tissues, the formation of presser angiotensin II would be curtailed and that of des-asp-angiotensin I enhanced. As des-asp-angiotensin I lacks direct vasopressor action, its preferential formation over that of angiotensin II could be a physiological response to the prevailing hypertension in the SHR. | |
dc.description.uri | http://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1016/S0378-4347(97)00005-4 | |
dc.source | Scopus | |
dc.subject | Aminopeptidase | |
dc.subject | Enzymes | |
dc.type | Article | |
dc.contributor.department | PHARMACOLOGY | |
dc.description.doi | 10.1016/S0378-4347(97)00005-4 | |
dc.description.sourcetitle | Journal of Chromatography B: Biomedical Applications | |
dc.description.volume | 697 | |
dc.description.issue | 1-2 | |
dc.description.page | 259-262 | |
dc.description.coden | JCBBE | |
dc.identifier.isiut | A1997XX47000025 | |
Appears in Collections: | Staff Publications |
Show simple item record
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.