Please use this identifier to cite or link to this item: https://doi.org/10.1016/S0891-5849(99)00143-4
Title: Mitochondrial damage by the 'pro-oxidant' peroxisomal proliferator clofibrate
Authors: Qu, B.
Li, Q.-T. 
Wong, K.P.
Halliwell, B. 
Ong, C.N. 
Keywords: 8-Hydroxy-2'-deoxyguanosine
Clofibrate
Free radicals
Mitochondria
Peroxisome proliferator
Protein carbonyls
Issue Date: 1999
Source: Qu, B., Li, Q.-T., Wong, K.P., Halliwell, B., Ong, C.N. (1999). Mitochondrial damage by the 'pro-oxidant' peroxisomal proliferator clofibrate. Free Radical Biology and Medicine 27 (9-10) : 1095-1102. ScholarBank@NUS Repository. https://doi.org/10.1016/S0891-5849(99)00143-4
Abstract: Clofibrate is a peroxisome proliferator that can cause hepatic cancer in rodents. It has been suggested that oxidative damage is involved in this hepatocarcinogenesis, although the data are conflicting. We confirmed that clofibrate causes oxidative damage in nuclei from the livers of mice treated with this substance, measured both as protein carbonyls and levels of 8-hydroxy-2'-deoxyguanosine (8-OHdG) in DNA. In addition, clofibrate also affects mitochondria, causing elevated levels of carbonyls and 8-OHdG, increased state 4 respiration and decreased adenosine triphosphatase (ATPase) activity. No evidence for clofibrate-induced lipid peroxidation in mitochondria was obtained. We propose that mitochondria may be a major target of injury and a source of oxidative stress in clofibrate-treated animals. Copyright (C) 1999 Elsevier Science Inc.
Source Title: Free Radical Biology and Medicine
URI: http://scholarbank.nus.edu.sg/handle/10635/32042
ISSN: 08915849
DOI: 10.1016/S0891-5849(99)00143-4
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